Seminars in Spine Surgery
Volume 22, Issue 3 , Pages 110-112, September 2010

Etiology of Congenital Scoliosis

  • Frances A. Farley, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Frances A. Farley, MD, Department of Orthopaedic Surgery, University of Michigan, 1500 East Medical Center Dr., TC 2912, Ann Arbor, MI 48109

Pediatric Orthopaedic Service, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI

published online 10 May 2010.

Congenital scoliosis may have an environmental or genetic etiology. Environmental etiologies have focused on maternal carbon monoxide exposure in mice early in gestation. Genetic studies have focused on skeletal patterning genes in the human and the mouse. Genetic mutations have been isolated in the related Jarcho-Levin syndrome.

Keywords: congenital scoliosis, environmental factors, genetic factors

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 This work was supported by a Congenital Scoliosis Center Grant, Department of Orthopaedic Surgery, University of Michigan, Ann Arbor, MI.

PII: S1040-7383(10)00020-1

doi:10.1053/j.semss.2010.03.001

Seminars in Spine Surgery
Volume 22, Issue 3 , Pages 110-112, September 2010

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