Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 26-32 , March 2006

Growth and Differentiation Factor-5: New Frontiers to Bone Repair and Spinal Fusion

  • Chantal E. Holy, PhD

      Affiliations

    • DePuy Spine, Raynham, MA, USA
  • ,
  • F. Jerry Volenec, PhD

      Affiliations

    • DePuy Spine, Raynham, MA, USA
  • ,
  • Jens Pohl, PhD

      Affiliations

    • Biopharm, Heidelberg, Germany
  • ,
  • Rolf Bechtold, PhD

      Affiliations

    • Biopharm, Heidelberg, Germany
  • ,
  • Scott P. Bruder, MD, PhD

      Affiliations

    • DePuy Spine, Raynham, MA, USA
    • Corresponding Author InformationAddress reprint requests to Scott P. Bruder, MD, PhD, DePuy Biologics, a division of DePuy Spine, 325 Paramount Drive, Raynham, MA 02767

References 

  1. Cheng H , Jiang W , Phillips FM , et al.   Osteogenic activity of the fourteen types of human bone morphogenetic proteins (BMPs) . J Bone Joint Surg (Am) . 2003;85A(8):1544–1552
  2. Triantafilou K , Triantafilou M , Dedrick RL . A CD14-independent LPS receptor cluster . Nat Immunol . 2001;2(4):338–345
  3. Chang SC , Hoang B , Thomas JT , et al.   Cartilage-derived morphogenetic proteins. New members of the transforming growth factor-beta superfamily predominantly expressed in long bones during human embryonic development . J Biol Chem . 1994;269(45):28227–28234
  4. Hotten G , Neidhardt H , Jacobowsky B , et al.   Cloning and expression of recombinant human growth/differentiation factor 5 . Biochem Biophys Res Commun . 1994;204(2):646–652
  5. Buxton P , Edwards C , Archer CW , et al.   Growth/differentiation factor-5 (GDF-5) and skeletal development . J Bone Joint Surg (Am) . 2001;83A:23–306 (suppl)
  6. Merino R , Macias D , Ganan Y , et al.   Expression and function of GDF-5 during digit skeletogenesis in the embryonic chick leg bud . Dev Biol . 1999;206:33–45
  7. Storm EE , Huynh TV , Copeland NG , et al.   Limb alterations in brachypodism mice due to mutations in a new member of the TGF beta-superfamily . Nature . 1994;368:639–643
  8. Thomas JT , Lin K , Nandedkar M , et al.   A human chondrodysplasia due to a mutation in a TGF-beta superfamily member . Nat Genet . 1996;12:315–331
  9. Thomas JT , Kilpatrick MW , Lin K , et al.   Disruption of human limb morphogenesis by a dominant negative mutation in CDMP1 . Nat Genet . 1997;17:58–64
  10. Nishitoh H , Ichijo H , Kimura M , et al.   Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 . J Biol Chem . 1996;271:21345–21352
  11. Kirsch T , Nickel J , Sebald W . BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II . EMBO J . 2000;19:3314–3324
  12. Seemann P , Schwappbacher R , Kjaer K , et al.   Activating and deactivating mutations in the receptor-binding site of GDF-5 cause brachydactyly and symphalangism phenotypes . J Clin Invest . 2005;115:2373–2381
  13. Ganski L, Seeman P, Pohl J, et al: Single point mutation in recombinant human growth and differentiation factor-5 forms ectopic bone in a subcutaneous rat model. Orthop Res Soc, Chicago 2006 (in press)
  14. Tay KB , AX LE , Heilman M , et al.   Use of a collagen-hydroxyapatite matrix in spinal fusion, a rabbit model . Spine . 1998;23(21):2276–2281
  15. Thompson A , Merck A , Anudokem G , et al.   Bone regeneration by implants of mineralized collagen (HEALOS®) in rat cranial defects . Orthop Res Soc . 2001;634
  16. Jayaraman VM, Jayo MJ, Holy CE, et al: Growth and differentiation factor-5 successfully regenerates bone tissue in a critical-size rat cranial model. Orthop Res Soc, Chicago 2006 (in press)
  17. Boden SD , Schimandle JH , Hutton WC , et al.   An experimental lumbar intertransverse process spinal fusion model (radiographic, histologic, and biomechanical healing characteristics) . Spine . 1995;20:412–420
  18. Magit D , Maak R , Hammouri Q , et al.   HEALOS/rhGDF-5 induces fusion in a rabbit posterolateral lumbar fusion model . North Am Spine Soc . 2005;179S
  19. Thompson AY , Malmstrom D , Holy CE , et al.   Rabbit posterolateral fusion is achieved with recombinant human growth and differentiation factor-5 . North Am Spine Soc . 2005;95S
  20. Chen D , Zhao M , Mundy GR . Bone morphogenetic proteins . Growth Factors . 2004;22(4):233–241
  21. Spiro RC , Liu L , Heidaran MA . Inductive activity of recombinant human growth and differentiation factor-5 . Biochem Soc Trans . 2000;28:362–368
  22. Kim DH , Jahng TA , Fu TS , et al.   Evaluation of HEALOS/MP52 osteoinductive bone graft for instrumented lumbar intertransverse process fusion in sheep . Spine . 2004;29(24):2800–2808
  23. Jahng TA , Fu TS , Cunningham BW , et al.   Endoscopic instrumented posterolateral lumbar fusion with HEALOS and recombinant human growth/differentiation factor-5 . Neurosurgery . 2004;54(1):171–181
  24. Gupta MC , Turner SA , Seim HB , et al.   Anterior interbody spine fusion in sheep using a PEEK Cage and HEALOS/rhGDF-5 osteoinductive bone graft . Int Soc Study Lumbar Spine . 2005;132
  25. Attawia M , Chujo T , Akeda K , et al.   In vivo effects of recombinant human growth and differentiation factor 5 on the intervertebral disc . Eur Cells Mater . 2005;10(3):48; (suppl)
  26. Alexander J , Branch C . Recombinant human bone morphogenetic protein-2 in a posterior lumbar interbody fusion construct (2-year clinical and radiologic outcomes) . Spine J . 2002;2:48; (suppl)
  27. Dawson EG . Letters to the Editor . Spine J . 2003;3:87–89
  28. Fritzell P , Hagg O , Wessberg P , et al.   Lumbar fusion versus nonsurgical treatment for chronic low back pain (a multicenter randomized controlled trial from the Swedish Lumbar Spine Study Group) . Spine . 2001;26(23):2521–2532
  29. Brox JI , Sorensen R , Friis A , et al.   Randomized clinical trial of lumbar instrumented fusion and cognitive intervention and exercises in patients with chronic low back pain and disc degeneration . Spine . 2003;28(17):1913–1921
  30. van der Veen H . Results from the first clinical investigation of the use of HEALOS®-MP52 bone graft material in the surgical treatment of non-critical size long bone defects . Orthop Res Soc . 2005;211

PII: S1040-7383(06)00007-4

doi: 10.1053/j.semss.2006.01.006

Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 26-32 , March 2006