Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 22-25 , March 2006

Demineralized Bone Matrix for Spinal Arthrodesis

  • Wellington K. Hsu, MD
    • ,
  • Jeffrey C. Wang, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Jeffrey C. Wang, MD, Associate Professor of Orthopaedic and Neurosurgery, Executive Director, UCLA Comprehensive Spine Center, Chief, Orthopaedic Spine Service, David Geffen School of Medicine, 1250 16th St., 7th Floor Tower, #745, Mail Code 703646, Santa Monica, CA

References 

  1. Bridwell KH , Sedgewick TA , O’Brien MF , et al.   The role of fusion and instrumentation in the treatment of degenerative spondylolisthesis with spinal stenosis . J Spinal Disord . 1993;6:461–472
  2. McGuire RA , Amundson GM . The use of primary internal fixation in spondylolisthesis . Spine . 1993;18:1662–1672
  3. West JL , Bradford DS , Ogilvie JW . Results of spinal arthrodesis with pedicle screw-plate fixation . J Bone Joint Surg Am . 1991;73:1179–1184
  4. Zdeblick TA . A prospective, randomized study of lumbar fusion. Preliminary results . Spine . 1993;18:983–991
  5. Ludwig SC , Kowalski JM , Boden SD . Osteoinductive bone graft substitutes . Eur Spine J . 2000;9(suppl 1):S119–S125
  6. Younger EM , Chapman MW . Morbidity at bone graft donor sites . J Orthop Trauma . 1989;3:192–195
  7. Silber JS , Anderson DG , Daffner SD , et al.   Donor site morbidity after anterior iliac crest bone harvest for single-level anterior cervical discectomy and fusion . Spine . 2003;28:134–139
  8. Ahlmann E , Patzakis M , Roidis N , et al.   Comparison of anterior and posterior iliac crest bone grafts in terms of harvest-site morbidity and functional outcomes . J Bone Joint Surg Am . 2002;84A:716–720
  9. Boone DW . Complications of iliac crest graft and bone grafting alternatives in foot and ankle surgery . Foot Ankle Clin . 2003;8:1–14
  10. Seiler JG , Johnson J . Iliac crest autogenous bone grafting (donor site complications) . J South Orthop Assoc . 2000;9:91–97
  11. Banwart JC , Asher MA , Hassanein RS . Iliac crest bone graft harvest donor site morbidity. A statistical evaluation . Spine . 1995;20:1055–1060
  12. Goulet JA , Senunas LE , DeSilva GL , et al.   Autogenous iliac crest bone graft. Complications and functional assessment . Clin Orthop . 1997;76–81
  13. Reid RL . Hernia through an iliac bone-graft donor site. A case report . J Bone Joint Surg Am . 1968;50:757–760
  14. Coventry MB , Tapper EM . Pelvic instability (a consequence of removing iliac bone for grafting) . J Bone Joint Surg Am . 1972;54:83–101
  15. Challis JH , Lyttle JA , Stuart AE . Strangulated lumbar hernia and volvulus following removal of iliac crest bone graft . Acta Orthop Scand . 1975;46:230–233
  16. Cowley SP , Anderson LD . Hernias through donor sites for iliac-bone grafts . J Bone Joint Surg Am . 1983;65:1023–1025
  17. Kuhn DA , Moreland MS . Complications following iliac crest bone grafting . Clin Orthop . 1986;209:224–226
  18. Kurz LT , Garfin SR , Booth RE . Harvesting autogenous iliac bone grafts. A review of complications and techniques . Spine . 1989;14:1324–1331
  19. Price CT , Connolly JF , Carantzas AC , et al.   Comparison of bone grafts for posterior spinal fusion in adolescent idiopathic scoliosis . Spine . 2003;28:793–798
  20. Morone MA , Boden SD . Experimental posterolateral lumbar spinal fusion with a demineralized bone matrix gel . Spine . 1998;23:159–167
  21. Russell JL , Block JE . Clinical utility of demineralized bone matrix for osseous defects, arthrodesis, and reconstruction (impact of processing techniques and study methodology) . Orthopedics . 1999;22:524–531 quiz 532-533
  22. Urist MR , Silverman BF , Buring K , et al.   The bone induction principle . Clin Orthop . 1967;53:243–283
  23. Urist MR , Dawson E . Intertransverse process fusion with the aid of chemosterilized autolyzed antigen-extracted allogeneic (AAA) bone . Clin Orthop . 1981;154:97–113
  24. Reddi AH , Huggins C . Biochemical sequences in the transformation of normal fibroblasts in adolescent rats . Proc Natl Acad Sci USA . 1972;69:1601–1605
  25. Finkemeier CG . Bone-grafting and bone-graft substitutes . J Bone Joint Surg Am . 2002;84A:454–464
  26. Berven S , Tay BK , Kleinstueck FS , et al.   Clinical applications of bone graft substitutes in spine surgery (consideration of mineralized and demineralized preparations and growth factor supplementation) . Eur Spine J . 2001;10(suppl 2):S169–S177
  27. Frenkel SR , Moskovich R , Spivak J , et al.   Demineralized bone matrix. Enhancement of spinal fusion . Spine . 1993;18:1634–1639
  28. Johnson EE , Urist MR , Finerman GA . Resistant nonunions and partial or complete segmental defects of long bones. Treatment with implants of a composite of human bone morphogenetic protein (BMP) and autolyzed, antigen-extracted, allogeneic (AAA) bone . Clin Orthop . 1992;277:229–237
  29. Kakiuchi M , Hosoya T , Takaoka K , et al.   Human bone matrix gelatin as a clinical alloimplant. A retrospective review of 160 cases . Int Orthop . 1985;9:181–188
  30. Lindholm TS , Nilsson OS , Lindholm TC . Extraskeletal and intraskeletal new bone formation induced by demineralized bone matrix combined with bone marrow cells . Clin Orthop . 1982;171:251–255
  31. Lindholm TS , Ragni P , Lindholm TC . Response of bone marrow stroma cells to demineralized cortical bone matrix in experimental spinal fusion in rabbits . Clin Orthop . 1988;230:296–302
  32. Lindholm TS , Urist MR . A quantitative analysis of new bone formation by induction in compositive grafts of bone marrow and bone matrix . Clin Orthop . 1980;150:288–300
  33. Ragni P , Lindholm TS . Interaction of allogeneic demineralized bone matrix and porous hydroxyapatite bioceramics in lumbar interbody fusion in rabbits . Clin Orthop . 1991;272:292–299
  34. Bostrom MP , Yang X , Kennan M , et al.   An unexpected outcome during testing of commercially available demineralized bone graft materials (how safe are the nonallograft components?) . Spine . 2001;26:1425–1428
  35. Connolly JF . Injectable bone marrow preparations to stimulate osteogenic repair . Clin Orthop . 1985;383:8–18
  36. Tiedeman JJ , Garvin KL , Kile TA , et al.   The role of a composite, demineralized bone matrix and bone marrow in the treatment of osseous defects . Orthopedics . 1995;18:1153–1158
  37. Aspenberg P , Johnsson E , Thorngren KG . Dose-dependent reduction of bone inductive properties by ethylene oxide . J Bone Joint Surg Br . 1990;72:1036–1037
  38. Munting E , Wilmart JF , Wijne A , et al.   Effect of sterilization on osteoinduction. Comparison of five methods in demineralized rat bone . Acta Orthop Scand . 1988;59:34–38
  39. Wang JC , Kanim LE , Nagakawa IS , et al.   Dose-dependent toxicity of a commercially available demineralized bone matrix material . Spine . 2001;26:1429–1435 1435–1436
  40. Strates BS , Stock AJ , Connolly JF . Skeletal repair in the aged (a preliminary study in rabbits) . Am J Med Sci . 1988;296:266–269
  41. Sammarco VJ , Chang L . Modern issues in bone graft substitutes and advances in bone tissue technology . Foot Ankle Clin . 2002;7:19–41
  42. Urist MR , Behnam K , Kerendi F , et al.   Lipids closely associated with bone morphogenetic protein (BMP)—and induced heterotopic bone formation. With preliminary observations of deficiencies in lipid and osteoinduction in lathyrism in rats . Connect Tissue Res . 1997;36:9–20
  43. Boden SD , Schimandle JH , Hutton WC . 1995 Volvo Award in basic sciences. The use of an osteoinductive growth factor for lumbar spinal fusion. Part II: Study of dose, carrier, and species . Spine . 1995;20:2633–2644
  44. Boden SD , Schimandle JH , Hutton WC . Lumbar intertransverse-process spinal arthrodesis with use of a bovine bone-derived osteoinductive protein. A preliminary report . J Bone Joint Surg Am . 1995;77:1404–1417
  45. Boden SD , Schimandle JH , Hutton WC . An experimental lumbar intertransverse process spinal fusion model. Radiographic, histologic, and biomechanical healing characteristics . Spine . 1995;20:412–420
  46. Martin GJ , Boden SD , Titus L , et al.   New formulations of demineralized bone matrix as a more effective graft alternative in experimental posterolateral lumbar spine arthrodesis . Spine . 1999;24:637–645
  47. Schwartz Z , Mellonig JT , Carnes DL , et al.   Ability of commercial demineralized freeze-dried bone allograft to induce new bone formation . J Periodontol . 1996;67:918–926
  48. Oakes DA , Lee CC , Lieberman JR . An evaluation of human demineralized bone matrices in a rat femoral defect model . Clin Orthop . 2003;413:281–290
  49. Peterson B , Whang PG , Iglesias R , et al.   Variable osteoinductivity in commercially available demineralized bone matrix preparations in a spine fusion model . J Bone Joint Surg Am . 2004;86-A:2243–2250
  50. Greenwald AS , Boden SD , Goldberg VM , et al.   Bone-graft substitutes (facts, fictions, and applications) . J Bone Joint Surg Am . 2001;83A:98–103 (suppl 2 Pt. 2)

PII: S1040-7383(06)00006-2

doi: 10.1053/j.semss.2006.01.004

Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 22-25 , March 2006

Article Tools

* Image Usage & Resolution