Demineralized Bone Matrix for Spinal Arthrodesis

Demineralized bone matrix, which is created through the acid extraction of the mineralized phase of bone, has been demonstrated to have rich osteoconductive capabilities as bone graft extenders in the augmentation of spinal arthrodesis. However, despite its promise as a scaffold in the induction of bone formation, many questions remain when given the choice between the number of commercial preparations available on the market today. Variations in the production of demineralized bone matrix such as the carrier used, quality of donor bone, and unique sterilization methods result in unpredictable biologic characteristics. For this reason, further study of efficacy in clinical and laboratory trials is needed.

Keywords:  demineralized bone matrix , spinal fusion , bone graft substitutes , spinal arthrodesis