Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 12-14 , March 2006

The Use of Osteogenic Protein-1 for Spinal Applications

  • Safdar N. Khan, MD

      Affiliations

    • Corresponding Author InformationAddress reprint requests to Safdar N. Khan, MD, Department of Orthopaedic Surgery, University of California, Davis Medical Center, 4860 Y Street, Suite 3800, Sacramento, CA 95817, USA
    • ,
  • Munish C. Gupta, MD

References 

  1. Cotler JM . Star AM (Complications of spinal fusion) . In:  Cotler JM ,  Cotler HB editor. Spine Fusions: Science and Technique. New York, NY . New York: Springer-Verlag; 1990;
  2. Younger EM , Chapman MW . Morbidity at bone graft donor site . J Orthop Trauma . 1989;3:192–195
  3. Grauer JN , Patel TC , Erulkar JS , et al.   Evaluation of OP-1 as a graft substitute for intertransverse process lumbar fusion . Spine . 2000;26:127–133
  4. Cook SD , Dalton JE , Tan EH , et al.   In vivo evaluation of recombinant human osteogenic protein (rhOP-1) implants as a bone graft substitute for spinal fusion . Spine . 1994;19:1655–1663
  5. Magin M , Delling G . Improved lumbar vertebral interbody fusion using rhOP-1 . Spine . 2001;26:469–478
  6. Chirossel JP, Gay E, Boutrand JP, et al: Stryker spine PEEK and titanium cages: Interbody fusion with OP-1 (BMP-7) vs autograft in a sheep model. Presented at Eurospine, Antwerp, Belgium, 2000
  7. Cunningham BW , Kanayama M , Parker LM , et al.   Osteogenic protein versus autologous interbody arthrodesis in the sheep thoracic spine . Spine . 1999;24:509–518
  8. Paramore CG , Lauryssen C , Rauzzino J , et al.   The safety of OP-1 for lumbar fusion with decompression (a canine study) . Neurosurgery . 1999;44:1151–1156
  9. Mermer M , Gupta MC , Wheeler DL , et al.   Efficacy of osteogenic protein-1 in a challenging multilevel fusion model . Spine . 2004;29(3):249–256
  10. Vaccaro AR , Patel T , Fischgrund J , et al.   A pilot study evaluating the safety and efficacy of OP-1 Putty (rhBMP-7) as a replacement for iliac crest autograft in posterolateral lumbar arthrodesis for degenerative spondylolisthesis . Spine . 2004;29(17):1885–1892
  11. Vaccaro AR , Patel T , Fischgrund J . A 2-year follow-up pilot study evaluating the safety and efficacy of op-1 putty (rhbmp-7) as an adjunct to iliac crest autograft in posterolateral lumbar fusions . Eur Spine J . 2005;14(7):623–629 Epub 2005 Jan 26

PII: S1040-7383(06)00004-9

doi: 10.1053/j.semss.2006.01.005

Seminars in Spine Surgery
Volume 18, Issue 1 , Pages 12-14 , March 2006

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